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Also known as ALS or Lou Gehrig’southward disease, amyotrophic lateral sclerosis is a rare neurological disease involving the breakdown, and eventual death, of neurons that control voluntary muscles. The brain loses the ability to initiate and control motility, often resulting in an inability to eat, speak, move, and even breathe. Approximately 5,000 people in the US are diagnosed with this status per twelvemonth, according to the ALS Foundation. In that location are treatments for ALS, but there is no cure.

Coordination

Loss of coordination is one of the start warning signs of ALS. Reduced paw-eye coordination may start slowly, with the individual noticing relatively minor problems, such as the ability to grasp a hairbrush. Over time, the number of episodes increases in frequency, and in some cases
coordination bug
last
for months
before other symptoms brainstorm to appear.

Cramps

An early on alarm sign of ALS is
cramps
or
musculus spasms, peculiarly when they develop with other symptoms. Cramping, twitching, and atrophy of the muscles occur when spinal and brain stem motor neurons deteriorate. This detail symptom typically begins after the loss of hand-eye coordination and can final through many of the illness’s stages.

Weak Muscles

ALS almost immediately begins to wreak havoc on the nervous system. Motor neurons that tell muscles to move begin to dice, and every bit a result, individuals
lose control
of
and force
in their muscles. The degeneration of neurons leads to loss of muscle mass, too. Due to the lack of muscle mass, people with ALS ofttimes require wheelchairs fifty-fifty earlier they lose the ability to walk.

Vocal Pitch Changes

Laryngeal dysfunction can occur when the loss of neurons affects the bulbar nerves. Individuals with ALS often experience
changes
in
phonation pitch, usually resulting in speaking at a lower annals. This common symptom typically coincides with manus-eye coordination bug.

Slurred Oral communication

Slurring
of
voice communication
happens for a dissimilar reason than the alter in vocal pitch. This symptom occurs when the person is no longer capable of properly moving muscles involved with speech, including the lips and tongue. This is generally referred to as dysarthria, the inability to speak correctly due to loss of motor office. The individual affected may discover it difficult to pronounce words properly.

Crying and Laughing Uncontrollably

Some people with ALS experience significant mood swings that tin result in
uncontrollable
laughter
or crying, known as the pseudobulbar affect. Although it is not completely understood why this occurs, it is believed that when upper motor neurons, located in the cognitive cortex and brain stem, deteriorate, the disrupted neural pathways result in a deficiency of inhibition control. Emotions can come up on suddenly, without warning, and often without triggers, lasting only a few moments or up to an hr. Prescription medications can assist control the onset and distension of emotions.

Breathing Bug

Problematic animate does not occur immediately in all people with ALS, but near experience it somewhen. Equally muscles deteriorate, those responsible for bringing air in and out of the lungs are also afflicted. An individual may outset develop shortness of breath and an
inability to
breathe
in deeply. This can progress to complanate lungs and a continuous need for a breathing machine.

Problems with Walking

Trouble walking is a common ALS symptom usually seen in later stages of the affliction. Initially, an individual may experience
weakness
in
the legs, which gradually worsens as the disease continues to cause musculus degradation. In that location are many possible causes of weakness in the legs; all the same, most people with ALS experience other symptoms before this one peaks.

Problems Swallowing

Swallowing issues are some other belatedly symptom of ALS. The issue can make information technology
difficult to
eat
and drink, which makes choking a constant danger as information technology becomes difficult even to swallow saliva. This symptom is acquired by the lack of control of the muscles used when swallowing. Primary doctors may work with dietitians to devise meal plans that ensure individuals with ALS continue to become proper nutrition.

Difficulty Supporting the Head

People with advanced ALS oftentimes experience an inability to control the muscles in the cervix, resulting in a condition chosen
dropped
head
syndrome. The muscles at the back of the neck weaken, which is why people with ALS often require neck braces.